Imunitní systém a colostrum
Akisu, C, et al. Effect of human milk and colostrum on Entamoeba histolyica. World Journal of Gastroenterology 10(5):741-742 (2004). Colostrum was found to provide protection against Entamoeba histolyica, the cause of amoebiasis, a serious, chronic illness characterized by dysentery, gastrointestinal ulceration and abscess formation and intestinal blockage in infants particularly.
Armogida, SA, Yannaras, NM, Melton, AL, Srivastava, MD. (2004). Identification and quantification of innate immune system mediators in human breast milk. Allergy and Asthma Proceedings 25(5):297-304. Mediators of the innate immune system were determined in human colostrum. Human neutrophil-derived a-defensin 1 (HNP-1) and human beta-defensin 2 (HBD-2) were present in high amounts, human alpha-defensin 6 (HD-6) was present in moderate amounts, and HD-5 and HBD-1 were present in the lowest concentrations. HNP-1, HD-5 and HD-6 were present in significantly higher amounts in colostrum than in mature milk. It is believed that the innate immune system provides protection for both maternal breast tissue and the developing digestive system of newborns.
Blach-Olszewska, Z, Janusz, M. Stimulatory effect of ovine colostrinine (a proline-rich polypeptide) on interferons and tumor necrosis factor production by murine resident peritoneal cells. Archivum immunologiae et therapiae experimentalis (Warszava) 45(1):43-47 (1997).
Brüssow, H., et al. Bovine milk immunoglobulins for passive immunity to infantile rotavirus gastroenteritis. Journal of Clinical Microbiology 25(6):982-986 (1987). Protection against rotavirus, a dangerous pathogen which can cause serious, even fatal diarrhea in infants, can be passed orally through milk or colostrum safely and effectively.
Cesarone, MR, Belcaro, G, Di Renzo, A, Dugall, M, Cacchio, M, Ruffini, I, Pellegrini, L, Del Boccio, G, Fano, F, Ledda, A, Bottari, A, Ricci, A, Stuard, S, Vinciguerra, G. (2007) Prevention of influenza episodes with colostrum compared with vaccination in healthy and high-risk cardiovascular subjects: the epidemiologic study in San Valentino. Clinical and Applied Thrombosis/Hemostasis 13(2):13-6. Two month supplementation with oral colostrum was compared to anti-influenza vaccination in the prevention of flu. Colostrum was at least three times more effective than vaccination in preventing flu.
Collier, RJ, et al. Factors affecting insulin-like growth factor-I concentration in bovine milk. Journal of Dairy Science 74(9):2905-2911 (1991). IGF-1 levels are highest in colostrum and lower in mature milk. Concentration was not altered by pasteurization (79°C for 45 seconds) but was undetectable at higher temperatures (121°C for 5 minutes) used for infant formula preparation and in commercial infant formula.
Dominguez, E, et al. Effect of heat treatment on the antigen-binding activity of anti-peroxidase immunoglobulins in bovine colostrum. Journal of Dairy Science 80(12):3182-3187 (1997). A negative correlation was made between temperature and time in the denaturation of IgG, i.e. the higher the temperature, the shorter the time needed for denaturation to occur.
Dwyer, J. M. Manipulating the Immune System with Immune Globulin. New Engl. J. Med. 326(2):107-116. Jan. 9, 1992.
Janusz, M, Staroscik, K, Zimecki, M, Wieczorek, Z, Lisowski, J. A proline-rich polypeptide (PRP) with immunoregulatory properties isolated from ovine colostrum. Murine thymocytes have on their surface a receptor specific for PRP. Archivum immunologiae et therapiae experimentalis (Warszava) 34(4):427-436 (1986).
Janusz, M, Lisowski, J. Proline-rich polypeptide (PRP)--an immunomodulatory peptide from ovine colostrum. Archivum immunologiae et therapiae experimentalis (Warszava) 41(5-6):275-279 (1993).
Korhonen, H, et al. Bovine milk antibodies for health. British Journal of Nutrition 84(Suppl.1):S135-S146 (2000). Bovine colostrum provides safe, effective protection against many pathogens. This natural immune protection can be extended by hyperimmunizing cows against specific pathogens.
Solomons, N. W., Modulation of the immune system and the response against pathogens with bovine colostrum concentrates. European Journal of Clinical Nutrition 56(Suppl.3):S24-S28 (2002).
Stephan, W., et al., Antibodies from colostrum in oral immunotherapy. J. Clin. Chem. Clin. Biochem. 1990. 28: p. 19-23.
Solomons NW. Eur J Clin Nutr. 2002 Aug;56 Suppl 3:S24-8. Related Articles, Links, Modulation of the immune system and the response against pathogens with bovine colostrum concentrates. Center for Studies of Sensory Impairment, Aging and Metabolism, (CeSSIAM), Guatemala City, Guatemala.
Stephan, W, et al. Antibodies from colostrum in oral immunotherapy. Journal of Clinical Chemistry and Clinical Biochemistry 28:19-23 (1990). An immunoglobulin preparation from pooled bovine colostrum was found to be very effective in treating severe diarrhea, such as often found in AIDS patients.
Wilson, D.C., J. Immune system breakthrough: colostrum. Journal of Longevity. 4(2), 1998.
Zimecki, M, Janusz, M, Staroscik, K, Wieczorek, Z, Lisowski, J. Immunological activity of a proline-rich polypeptide from ovine colostrum. Archivum immunologiae et therapiae experimentalis (Warszava) 26(1-6):23-29 (1978).
Zimecki, M, Lisowski, J, Hraba, T, Wieczorek, Z, Janusz, M, Staroscik, K. The effect of a proline-rich polypeptide (PRP) on the humoral immune response. II. PRP induces differentiation of helper cells from glass-nonadherent thymocytes (NAT) and suppressor cells from glass-adherent thymocytes (GAT). Archivum immunologiae et therapiae experimentalis (Warszava) 32(2):197-201 (1984).
Zimecki, M, Artym, J. Therapeutic properties of proteins and peptides from colostrum and milk. Post?py Higieny i Medycyny Doswiadczalne j 59:309-323 (2005).