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Laktoferrin a colostrum

Zimecki, M, Spiegel, K, Wlaszczyk, A, Kubler, A, Kruzel, ML. (1999). Lactoferrin increases the output of neutrophil precursors and attenuates the spontaneous production of TNF-alpha and IL-6 by peripheral blood cells. Archivum Immunologiae et Therapie Experimentalis 47(2):113-118. Lactoferrin supplementation profoundly decreased the product of TNF-alpha and IL-6 (pro-inflammatory cytokines) in blood cultures while causing a transient increase of immature neutrophils in the blood.

Ward, PP, et al. Lactoferrin and host defense. Biochemistry and Cell Biology 80(1):95-102 (2002). Lactoferrin is a prominent component of the first line of defense against infection and inflammation. It accomplishes its activity through a variety of methods, most notably iron sequestration and its effect on down-regulating TNF-a, which controls the inflammatory cascade.

Shin K, Yamauchi K, Teraguchi S, et al. (1998) Antibacterial activity of bovine lactoferrin and its peptides against enterohaemorrhagic E. coli O157:H7. Letters in Applied Microbiology. 26:407-411.

Petschow B, Talbott R, Batema R. (1999) Ability of lactoferrin to promote the growth of Bifidobacterium spp. in vitro is independent of receptor binding capacity and iron saturation level. Journal of Microbiology. 48:541-549.

Kawakami H. (1988) Effects of iron-saturated Lactoferrin on iron absorption. Agric. Biol. Chem. 52:903-908.

Ikeda M, Sugiyama K, Tanaka T, et al. (1998) Lactoferrin markedly inhibits hepatitis C virus infection in cultured human hepatocytes. Biochemical and biophysical research communications 245:549-553.

Hasegawa, K, et al. Inhibition with lactoferrin of in vitro infection with human herpes virus. Japanese Journal of Medical Science and Biology 47:73-85 (1994). Both human and bovine lactoferrin inhibit infection with human herpes simplex virus and human cytomegalovirus in cell cultures.

Spik,G. et. al., Immunology, Vol. 35 No 4, 663-671. (Bovine) Colostrum contains a special iron binding protein called Lactoferrin which was demonstrated at the Clinical Research \center, Harrow, England to be highly antibacterial.

Nakao K; Imoto I; Ikemura N; Shibata T; et al; Relation of lactoferrin level in gastric mucosa with Helicobacter pylori infection and with the degree of gastric inflamnation. AM J Gastroenterol 1997 Jun;92 [6]:1005-11.

Nakao K.;Imoto I; Gabazza EC; Yamauchi K; et al; Gastric juice level of lactoferrin and Helicobacter pylori infection. Scand J Gastroenterol, 1997, Jun;32[6]:530-4.